Medical Research

Nitric Oxide Analysis

Zysense manufactures the Sievers Nitric Oxide Analyzer (NOA) for nitric oxide research and analysis. In biological systems, nitric oxide is produced from the enzymatic oxidation of arginine. Three isoforms of the enzyme nitric oxide synthase (NOS) have been identified in many cell types: endothelial NOS, neuronal NOS, and inducible NOS. The biological functions of NO include action as a vasodilator, neurotransmitter, cytotoxic agent, inhibit of platelet aggregation, and activator of smooth muscle proliferation.

Nitric oxide is also present in exhaled breath and may be a useful marker of airway inflammation.

In solution, nitric oxide reacts with molecular oxygen to form nitrite (NO2-), and with oxyhemoglobin and superoxide anion (O2-) to form nitrate (NO3-). NO also reacts with thiols to form S-nitroso compounds, amines to form nitrosamines, and metals to form metal nitrosylcomplexes.

The Sievers Nitric Oxide Analyzer (NOA 280i) offers the most versatile detection system for Nitric Oxide (NO) analysis. Zysense highly sensitive, ozone-chemiluminescence technology, the NOA 280i has unsurpassed versatility for liquid and exhaled breath NO measurement. With over 10000 publications using the Sievers Nitric Oxide Analyzer, the NOA has proven to be the instrumentation of choice by researchers worldwide.